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WebKitGTK API Versions Demystified
Quoting: WebKitGTK API Versions Demystified – Michael Catanzaro's Blog —
webkitgtk-6.0 contains a bunch of API changes, and all deprecated APIs were removed. If you’re upgrading to webkitgtk-6.0, then you’re also upgrading your application from GTK 3 to GTK 4, and have to adapt to much bigger GTK API changes anyway, so this seemed like a good opportunity to break compatibility and fix old mistakes for the first time in a very long time.
webkit2gtk-4.1 is exactly the same as webkit2gtk-4.0, except for the libsoup API version that it links against.